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compound 16a, a brs-3 agonist  (Bachem)

 
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    Bachem compound 16a, a brs-3 agonist
    Compound 16a, A Brs 3 Agonist, supplied by Bachem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compound 16a, a brs-3 agonist/product/Bachem
    Average 90 stars, based on 1 article reviews
    compound 16a, a brs-3 agonist - by Bioz Stars, 2026-05
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    Prostaglandin activation of BRS-3. A) Prostaglandins dose–response curve in HEK cells stably expressing BRS-3 receptors. BRS-3 agonist <t>16a</t> was used as positive control. B) Inhibitory effects of BRS-3 antagonists on PGE2 induced Ca2+ mobilization in BRS-3 stable cells. Bantag-1 dose-dependently inhibits PGE2 (5 nM) induced response (left). NMB receptor antagonist D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-NaI-NH2 dose-dependently inhibits PGE2 (5 nM) induced response (right). C) No PGE2 induced Ca2+ mobilization in HEK cells expressing NMB (left) and GRP receptors (right). Error bars represent sem of triplicate measurements for each point.
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    Prostaglandin activation of BRS-3. A) Prostaglandins dose–response curve in HEK cells stably expressing BRS-3 receptors. BRS-3 agonist 16a was used as positive control. B) Inhibitory effects of BRS-3 antagonists on PGE2 induced Ca2+ mobilization in BRS-3 stable cells. Bantag-1 dose-dependently inhibits PGE2 (5 nM) induced response (left). NMB receptor antagonist D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-NaI-NH2 dose-dependently inhibits PGE2 (5 nM) induced response (right). C) No PGE2 induced Ca2+ mobilization in HEK cells expressing NMB (left) and GRP receptors (right). Error bars represent sem of triplicate measurements for each point.

    Journal: The FASEB Journal

    Article Title: Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3

    doi: 10.1096/fj.201700337RR

    Figure Lengend Snippet: Prostaglandin activation of BRS-3. A) Prostaglandins dose–response curve in HEK cells stably expressing BRS-3 receptors. BRS-3 agonist 16a was used as positive control. B) Inhibitory effects of BRS-3 antagonists on PGE2 induced Ca2+ mobilization in BRS-3 stable cells. Bantag-1 dose-dependently inhibits PGE2 (5 nM) induced response (left). NMB receptor antagonist D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-NaI-NH2 dose-dependently inhibits PGE2 (5 nM) induced response (right). C) No PGE2 induced Ca2+ mobilization in HEK cells expressing NMB (left) and GRP receptors (right). Error bars represent sem of triplicate measurements for each point.

    Article Snippet: Compound 16a, a BRS-3 agonist ( 23 ), N 1-(2-phenylethyl)-(2R)-2-{[(1S)-1-(benzylcarboxamido)ethyl]carboxamido}-3-([ 1 H]-3-indolyl)propanamide ( Supplemental Fig. S1 ), was purchased from Bachem Americas (Torrance, CA, USA).

    Techniques: Activation Assay, Stable Transfection, Expressing, Positive Control

    No effects of PGE2 may be observed in CHO-BRS-3 or HeLa-BRS-3 cells; 16a was used as positive control.

    Journal: The FASEB Journal

    Article Title: Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3

    doi: 10.1096/fj.201700337RR

    Figure Lengend Snippet: No effects of PGE2 may be observed in CHO-BRS-3 or HeLa-BRS-3 cells; 16a was used as positive control.

    Article Snippet: Compound 16a, a BRS-3 agonist ( 23 ), N 1-(2-phenylethyl)-(2R)-2-{[(1S)-1-(benzylcarboxamido)ethyl]carboxamido}-3-([ 1 H]-3-indolyl)propanamide ( Supplemental Fig. S1 ), was purchased from Bachem Americas (Torrance, CA, USA).

    Techniques: Positive Control

    Calcium responses in HEK, CHO, and HeLa cells

    Journal: The FASEB Journal

    Article Title: Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3

    doi: 10.1096/fj.201700337RR

    Figure Lengend Snippet: Calcium responses in HEK, CHO, and HeLa cells

    Article Snippet: Compound 16a, a BRS-3 agonist ( 23 ), N 1-(2-phenylethyl)-(2R)-2-{[(1S)-1-(benzylcarboxamido)ethyl]carboxamido}-3-([ 1 H]-3-indolyl)propanamide ( Supplemental Fig. S1 ), was purchased from Bachem Americas (Torrance, CA, USA).

    Techniques: Plasmid Preparation

    Crosstalk between BRS-3 and EP3 receptors in CHO cells. A) Enhanced response to PGE2 (1 μM) in CHO-EP3 (2 μg)/BRS-3 (5 μg) cells. B, C) Dose–response of BRS-3 (B) and EP3 (C) on PGE2 (1 μM) induced Ca2+ influx in CHO-EP3/BRS-3. D, E) Effects of EP3 (L-798,106, 10 μM; Sigma-Aldrich) and BRS-3 antagonists (bantag-1, 10 μM; Sigma-Aldrich) on PGE2 (1 μM) (D) or 16a (1 μM) (E) induced Ca2+ influx in CHO-EP3 (2 μg)/BRS-3 (5 μg) cells. F) No inhibitory effect of bantag-1 on PGE2 response in CHO-EP3 cells. Error bars represent sem of triplicate measurements for each point.

    Journal: The FASEB Journal

    Article Title: Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3

    doi: 10.1096/fj.201700337RR

    Figure Lengend Snippet: Crosstalk between BRS-3 and EP3 receptors in CHO cells. A) Enhanced response to PGE2 (1 μM) in CHO-EP3 (2 μg)/BRS-3 (5 μg) cells. B, C) Dose–response of BRS-3 (B) and EP3 (C) on PGE2 (1 μM) induced Ca2+ influx in CHO-EP3/BRS-3. D, E) Effects of EP3 (L-798,106, 10 μM; Sigma-Aldrich) and BRS-3 antagonists (bantag-1, 10 μM; Sigma-Aldrich) on PGE2 (1 μM) (D) or 16a (1 μM) (E) induced Ca2+ influx in CHO-EP3 (2 μg)/BRS-3 (5 μg) cells. F) No inhibitory effect of bantag-1 on PGE2 response in CHO-EP3 cells. Error bars represent sem of triplicate measurements for each point.

    Article Snippet: Compound 16a, a BRS-3 agonist ( 23 ), N 1-(2-phenylethyl)-(2R)-2-{[(1S)-1-(benzylcarboxamido)ethyl]carboxamido}-3-([ 1 H]-3-indolyl)propanamide ( Supplemental Fig. S1 ), was purchased from Bachem Americas (Torrance, CA, USA).

    Techniques: